Enzymatic Crosslinked Hydrogels for Biomedical Application

Self-assembled structures primarily arise through enzyme-regulated phenomena in nature under persistent conditions. Enzymatic reactions are one of the main biological processes constructing supramolecular hydrogel networks required for biomedical applications. Such enzymatic provide a unique opportunity to integrate formation. In most cases, structure and substrates hydrogels adjusted by enzyme catalysis due enzymes’ chemo-, regio- stereo-selectivity. processed using various schemes showed remarkable characteristics as dynamic frames cells, bioactive molecules, drugs tissue engineering, drug delivery, regenerative medicine. The enzyme-mediated crosslinking mimic extracellular matrices displaying physicochemical properties functionalities such water-retention capacity, biodegradability, biocompatibility, biostability, bioactivity, optoelectronic properties, self-healing ability, shape memory ability. recent years, many systems investigated polymer crosslinking. Herein, we review efficient strategies hydrogelation, including synthesis chemistry, demonstrate their applicability systems. Furthermore, advantages, challenges, prospects enzymatic-crosslinkable discussed. results biocompatible products show that these mechanisms can fulfill requirements variety applications, wound healing, delivery.